Nanoparticles in dentistry to combat bacterial biofilm formation: a systematic review

Authors

DOI:

https://doi.org/10.61347/rcss.v1i1.e1

Keywords:

Bacterial biofilms, dentistry, nanoparticles, synthesis

Abstract

Introduction: The formation of bacterial biofilms represents one of the main challenges in maintaining oral health, particularly in clinical contexts such as dental caries and periodontitis. In this context, nanoparticles have emerged as an innovative strategy in dentistry due to their antimicrobial potential.

Objective: This study aimed to analyze, through a systematic literature review, the applications of nanoparticles in the prevention and treatment of oral biofilms.

Methods: A search was conducted in the Scopus database, identifying a total of 232 articles, from which 58 primary studies were selected after applying inclusion and exclusion criteria, as well as bias assessment.

Results: The results showed that silver nanoparticles (AgNPs) exhibit notable antimicrobial activity against microorganisms such as Streptococcus mutans and Porphyromonas gingivalis. Promising properties were also identified in zinc oxide (ZnO) and titanium dioxide (TiO₂) nanoparticles. The variety of synthesis methods and characterization techniques employed in the reviewed studies reflects the dynamism and complexity of the field.

Conclusions: The review highlights the therapeutic potential of nanoparticles in controlling oral biofilms and emphasizes the need for further research on their long-term safety and efficacy.

References

Bai X, Lin C, Wang Y, Ma J, Wang X, Yao X, et al. Preparation of Zn doped mesoporous silica nanoparticles (Zn-MSNs) for the improvement of mechanical and antibacterial properties of dental resin composites. Dent Mater. 2020;36(6):794-807. Disponible en: https://doi.org/10.1016/j.dental.2020.03.026

Beketova A, Tzanakakis EGC, Vouvoudi E, Anastasiadis K, Rigos AE, Pandoleon P, et al. Zirconia Nanoparticles as Reinforcing Agents for Contemporary Dental Luting Cements: Physicochemical Properties and Shear Bond Strength to Monolithic Zirconia. Int J Mol Sci [Internet]. 2023;24(3). Disponible en: https://doi.org/10.3390/ijms24032067

Kumaravel V, Nair KM, Mathew S, Bartlett J, Kennedy JE, Manning HG, et al. Antimicrobial TiO2 nanocomposite coatings for surfaces, dental and orthopaedic implants. Chem Eng J [Internet]. 2021;416. Disponible en: https://doi.org/10.1016/j.cej.2021.129071

Takamiya AS, Monteiro DR, Gorup LF, Silva EA, de Camargo ER, Gomes-Filho JE, et al. Biocompatible silver nanoparticles incorporated in acrylic resin for dental application inhibit Candida albicans biofilm. Mater Sci Eng C [Internet]. 2021;118. Disponible en: https://doi.org/10.1016/j.msec.2020.111341

Thyagarajan R, Narendrakumar G, Rameshkumar V, Varshiney M. Green synthesis of Zirconia nanoparticles based on ginger root extract: Optimization of reaction conditions, application in dentistry. Res J Pharm Technol. 2022;15(11):5314-20. Disponible en: http://dx.doi.org/10.52711/0974-360X.2022.00895

Barot T, Rawtani D, Kulkarni P. Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications. Heliyon [Internet]. 2020;6(3). Disponible en: https://doi.org/10.1016/j.heliyon.2020.e03601

Jaisankar AI, Rajeshkumar S, Ezhilarasan D. Applications of silver nanoparticles in dentistry. Int J Res Pharm Sci. 2020;11(Special Issue 3):1126-31. Disponible en: https://doi.org/10.7759/cureus.44090

Kaptan Usul S, Aslan A, Lüleci HB, Ergüden B, Çöpoğlu MT, Oflaz H, et al. Investigation of antimicrobial and mechanical effects of functional nanoparticles in novel dental resin composites. J Dent [Internet]. 2022;123. Disponible en: https://doi.org/10.1016/j.jdent.2022.104180

Arslan S, Ekrikaya S, Ildiz N, Yusufbeyoglu S, Ocsoy İ. Evaluation of the antibacterial activity of dental adhesive containing biogenic silver nanoparticles decorated nanographene oxide nanocomposites (Ag@nGO NCs) and effect on bond strength to dentine. Odontology. 2024;112(2):341-54. Disponible en: https://doi.org/10.1007/s10266-023-00836-7

Gul N, Idrees QTA, Fareed MA, Mian SA, Nasim HMO, Naz F, et al. Biological and Physicochemical Characterization of Self-Adhesive Protective Coating Dental Restorative Material after Incorporation of Antibacterial Nanoparticles. Polym [Internet]. 2022;14(20). Disponible en: https://doi.org/10.3390/polym14204280

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. Declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas. Revista Española de Cardiología. 1 de septiembre de 2021;74(9):790-9. Disponible en: https://doi.org/10.1016/j.recesp.2021.06.016

Abbas RH, Haleem AM, Kadhim A. The antimicrobial effect of simultaneously applying different diode lasers and silver nanoparticles synthesized by laser ablation on bacterial dental caries. Appl Nanosci (Switzerland). 2023;13(8):5589-603. Disponible en: https://doi.org/10.1007/s13204-023-02776-8

Hossain N, Chowdhury DMA, Hossain A, Ahmed MS, Rana MM, Sultana S. Synthesis and characterization of Alocasia indica infused silver nanoparticles for dental implant applications. Chem Phys Impact [Internet]. 2023;6. Disponible en: https://doi.org/10.1016/j.chphi.2023.100239

Hamad AM, Atiyea QM. Study the Effect of Zinc Oxide Nanoparticles and Dianthus Caryophyllus L. Extract on Streptococcus Mutans Isolated from Human Dental Caries in Vitro. En: Jawad L.A.H.M., Hussain F.F.K., Almurshedi A.F., Ali T.H., Al-Mussawi H.K., Kadhem S.K., et al., editores. AIP Conf Proc [Internet]. American Institute of Physics Inc.; 2022. Disponible en: https://doi.org/10.1063/5.0094583

Wang Y, Ding Y, Deng J, Nie R, Meng X. Antibacterial one-step self-etching dental adhesive with silver nanoparticles synthesized in situ. J Dent [Internet]. 2023;129. Disponible en: https://doi.org/10.1016/j.jdent.2023.104411

Chifor E, Bordeianu I, Anastasescu C, Calderon-Moreno JM, Bratan V, Eftemie DI, et al. Bioactive Coatings Based on Nanostructured TiO2 Modified with Noble Metal Nanoparticles and Lysozyme for Ti Dental Implants. Nanomaterials. 14 de septiembre de 2022;12(18):3186. Disponible en: https://doi.org/10.3390/nano12183186

Ortiz-Magdaleno M, Sánchez-Vargas L, Gardea-Contreras D, Campos-Ibarra V, Pozos-Guillén A, Márquez-Preciado R. Antibiofilm properties of silver nanoparticles incorporated into polymethyl methacrylate used for dental applications. BME. 3 de julio de 2023;34(4):357-73. Disponible en: https://doi.org/10.3233/BME-222513

Khan A, Alhamdan Y, Alibrahim H, Almulhim K, Nawaz M, Ahmed S, et al. Analyses of Experimental Dental Adhesives Based on Zirconia/Silver Phosphate Nanoparticles. Polymers. 8 de junio de 2023;15(12):2614. Disponible en: https://doi.org/10.3390/polym15122614

Javed R, Rais F, Kaleem M, Jamil B, Ahmad MA, Yu T, et al. Chitosan capping of CuO nanoparticles: Facile chemical preparation, biological analysis, and applications in dentistry. International Journal of Biological Macromolecules. enero de 2021;167:1452-67. Disponible en: https://doi.org/10.1016/j.ijbiomac.2020.11.099

Hassan ZJS, Hamid MK, Ahmed ME. Synthesized Zinc Oxide Nanoparticles by The Precipitation Method on Streptococcus Spp From Dental Carries and Cytotoxicity Assay. IJDDT. 30 de junio de 2022;12(03):1327-30. https://doi.org/10.25258/ijddt.12.3.65

Al-Ansari MM, Al-Dahmash ND, Ranjitsingh AJA. Synthesis of silver nanoparticles using gum Arabic: Evaluation of its inhibitory action on Streptococcus mutans causing dental caries and endocarditis. Journal of Infection and Public Health. marzo de 2021;14(3):324-30. Disponible en: https://doi.org/10.1016/j.jiph.2020.12.016

Zhang M, Liu X, Xie Y, Zhang Q, Zhang W, Jiang X, et al. Biological Safe Gold Nanoparticle-Modified Dental Aligner Prevents the Porphyromonas gingivalis Biofilm Formation. ACS Omega. 4 de agosto de 2020;5(30):18685-92. Disponible en: https://doi.org/10.1021/acsomega.0c01532

Rodrigues MC, Rolim WR, Viana MM, Souza TR, Gonçalves F, Tanaka CJ, et al. Biogenic synthesis and antimicrobial activity of silica-coated silver nanoparticles for esthetic dental applications. J Dent [Internet]. 2020;96. Disponible en: https://doi.org/10.1016/j.jdent.2020.103327

Zhang M, Liu X, Xie Y, Zhang Q, Zhang W, Jiang X, et al. Biological Safe Gold Nanoparticle-Modified Dental Aligner Prevents the Porphyromonas gingivalis Biofilm Formation. ACS Omega. 2020;5(30):18685-92. Disponible en: https://doi.org/10.1021/acsomega.0c01532

Aguiar JD, Pedrosa MS, Toma SH, Araki K, Marques MM, Medeiros IS. Antibacterial effect, cytotoxicity, and bond strength of a modified dental adhesive containing silver nanoparticles. Odontology. 2023;111(2):420-7. Disponible en: https://doi.org/10.1007/s10266-022-00752-2

Chokkattu JJ, Mary DJ, Shanmugam R, Neeharika S. Evaluation of Clove and Ginger-mediated Titanium Oxide Nanoparticles-based Dental Varnish against Streptococcus mutans and Lactobacillus Species: An In Vitro Study. World J Dent. 2023;14(3):233-7. Disponible en: https://doi.org/10.5005/jp-journals-10015-2185

Weng L, Wu L, Guo R, Ye J, Liang W, Wu W, et al. Lactobacillus cell envelope-coated nanoparticles for antibiotic delivery against cariogenic biofilm and dental caries. J Nanobiotechnology [Internet]. 2022;20(1). Disponible en: https://doi.org/10.1186/s12951-022-01563-x

Published

2025-01-02

How to Cite

Mejía Mosquera, H. F., & Guamán Hernández, V. A. (2025). Nanoparticles in dentistry to combat bacterial biofilm formation: a systematic review. Salmus, 1(1), e1. https://doi.org/10.61347/rcss.v1i1.e1